Striatal topography of D-2 receptors correlates with indexes of cholinergic neuron localization

The topography of dopamine D-2 receptor sites determined from autoradiographs of the rat striatum was compared with previously published values for choline acetyltransferase activity and high-affinity choline uptake within subregions of the striatum. The density of D-2 sites in the caudate-putamen correlates strikingly with these indexes of cholinergic neuron distribution.