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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
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Prospective applications of microRNAs in oral cancer

Chuan Fang1, Yadong Li1

  • 1Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.

Oncology Letters
|October 4, 2019
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in oral cancer, influencing tumor progression and treatment response. Detecting specific miRNAs in bodily fluids offers potential for early diagnosis and novel therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are non-coding RNA molecules regulating gene expression post-transcriptionally.
  • Dysregulation of miRNAs is implicated in the development and progression of oral malignancies.
  • Aberrant miRNA levels are detectable in various biological samples from oral cancer patients.

Purpose of the Study:

  • To review the multifaceted roles of miRNAs in oral cancer.
  • To explore the potential of miRNAs as diagnostic and prognostic biomarkers.
  • To discuss miRNAs as therapeutic targets in oral cancer treatment.

Main Methods:

  • Literature review of studies investigating miRNA involvement in oral cancer.
  • Analysis of miRNA expression patterns in oral cancer cell lines, tissues, and biofluids.
  • Evaluation of miRNA functions in key oncogenic pathways.

Main Results:

  • miRNAs regulate critical processes including tumor growth, apoptosis, migration, invasion, and metastasis.
  • Altered miRNA profiles are associated with radiosensitivity and chemosensitivity in oral cancer.
  • miRNAs show promise as biomarkers for early detection and prognosis.

Conclusions:

  • miRNAs play significant roles in oral cancer pathogenesis and progression.
  • Circulating miRNAs in saliva, serum, and plasma represent promising minimally invasive biomarkers.
  • miRNAs offer potential as novel therapeutic targets for oral cancer management.
Keywords:
biomarkermicroRNAnon-invasive methodoral carcinomatarget gene

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