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Related Experiment Video

Updated: Jan 6, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

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Generating vascular conduits: from tissue engineering to three-dimensional bioprinting.

Renee M Maina1, Maria J Barahona1, Michele Finotti1,2

  • 1Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

Innovative Surgical Sciences
|October 4, 2019
PubMed
Summary

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Tissue engineering and 3D bioprinting offer new solutions for vascular grafts when autologous options are unavailable. Novel 3D bioprinting techniques create functional, scaffold-free vascular conduits with native vessel properties.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Science

Background:

  • Vascular diseases are a major global health burden, necessitating effective treatments.
  • Current treatments rely on autologous grafts, but donor site limitations and patient factors restrict their use.
  • A significant need exists for engineered vascular conduits that mimic native vessel properties.

Purpose of the Study:

  • To review advancements in tissue engineering and 3D bioprinting for vascular graft development.
  • To highlight the potential of 3D bioprinting for creating de novo vascular conduits.
  • To present novel scaffold-free, bioreactor-free 3D bioprinted vascular grafts.

Main Methods:

  • Review of existing literature on tissue-engineered vascular grafts.
Keywords:
graft fabricationvascular diseasevessel engineering

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  • Exploration of various 3D bioprinting strategies and cell-based inks.
  • Description of a specific method for creating 3D bioprinted vascular grafts using rat cells.
  • Main Results:

    • Tissue engineering approaches include using scaffolds and acellular compounds.
    • 3D bioprinting with cell-based inks shows promise for creating vascular structures.
    • Developed scaffold-free, bioreactor-free 3D bioprinted vessels demonstrated patency and native mechanical strength.

    Conclusions:

    • Tissue engineering and 3D bioprinting are crucial for addressing the shortage of suitable vascular grafts.
    • 3D bioprinting offers a versatile platform for fabricating patient-specific vascular conduits.
    • Scaffold-free, 3D bioprinted vessels represent a significant advancement in regenerative vascular medicine.