Related Experiment Video
Updated: Jan 6, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Association between environmental quality and diabetes in the USA
Jyotsna S Jagai1, Alison K Krajewski2, Sabina Shaikh3
1School of Public Health, Division of Environmental and Occupational Health Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Poor environmental quality, not just lifestyle, may influence diabetes rates. Comprehensive diabetes prevention should include improving environmental quality, especially in less urbanized areas.
Area of Science:
- Environmental health
- Epidemiology
- Public health
Background:
- Caloric excess and physical inactivity do not fully explain rising diabetes prevalence.
- Individual environmental pollutants can disrupt glucose homeostasis.
- The impact of cumulative environmental exposures on diabetes risk remains unclear.
Purpose of the Study:
- To investigate the association between cumulative environmental exposures and diabetes prevalence.
- To assess the impact of the Environmental Quality Index on diabetes rates across different rural-urban strata.
Main Methods:
- Developed a county-level Environmental Quality Index (EQI) from five domains.
- Linked EQI to county-level diabetes prevalence rates.
- Used mixed-effects linear regression to estimate prevalence differences (PD) and 95% confidence intervals (CI), stratified by rural-urbanicity.
Main Results:
- Counties with the poorest environmental quality showed lower total diabetes prevalence rates compared to those with the best quality.
- Better overall environmental quality correlated with lower diabetes prevalence in less urbanized strata.
- Good sociodemographic environments were linked to lower diabetes prevalence (PD 2.77 per 100,000).
Conclusions:
- Environmental exposures are significant contributors to diabetes pathogenesis.
- Improving environmental quality is crucial for comprehensive diabetes prevention strategies.
Related Concept Videos
Diabetes: Symptoms, Diagnosis, and Complications
Diabetes Mellitus: Type 2 and Gestational
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Psychoneuroimmunology: Diabetes and Cancer
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...

