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Updated: Jan 6, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Variations in laboratory parameters in prechronic disease to determine disease occurrence at the molecular level
Sun Wenping1, Liu Ying2, Li Yuzhong1,2
1College of Medical Laboratory, Dalian Medical University, Dalian, PR China.
Abstract:
Aim: Change at a molecular level should occur before histopathological impairments. We refer to these changes as 'prechronic disease state.' Methods: Two blood samples were taken 1 day apart, 1 month apart and 2 years apart to determine the contribution of genetic and biological variations. Results: The 95% CI calculated quantitatively by the variability of genetic variation was very similar to the reference interval provided by the laboratory for most indicators, indicating that pathological variability had occurred without consideration of biological variation if an indicator's value lies outside of the reference interval. Conclusion: The physiological or predisease state can be distinguished directly using the laboratory reference interval.
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