Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Study Designs in Epidemiology01:20

Study Designs in Epidemiology

840
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
840
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

126
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
126
Hypothesis Test for Test of Independence01:16

Hypothesis Test for Test of Independence

7.4K
The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
7.4K
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

227
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
227
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

375
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
375
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

170
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
170

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revue medicale suisse·2026
Same author

Revue medicale suisse·2026
Same author

[Addictions : what's new in 2025].

Revue medicale suisse·2026
Same author

Correction: Health Status of North African Adolescent and Young Adult Migrants in Europe: a Scoping Review.

Journal of immigrant and minority health·2025
Same author

Health Status of North African Adolescent and Young Adult Migrants in Europe: a Scoping Review.

Journal of immigrant and minority health·2025
Same author

Community-based participatory research to improve resident wellness in a supportive living facility in the Northwest Territories.

Harm reduction journal·2025

Related Experiment Video

Updated: Jan 6, 2026

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
08:05

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

10.1K

"Alcochoix+": controlled drinking within a structured programme - a cohort study in Switzerland.

Thierry Favrod-Coune1, Gaspard Aebischer1, Fabienne Grondin-Giletti1

  • 1Primary Care Unit, Geneva University Hospital, Switzerland.

Swiss Medical Weekly
|October 4, 2019
PubMed
Summary

This study evaluated a controlled drinking program for excessive and moderately dependent alcohol users. Fully participating individuals significantly reduced alcohol intake and improved quality of life, showing sustained results.

More Related Videos

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

1.2K
The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
05:40

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans

Published on: April 28, 2022

3.4K

Related Experiment Videos

Last Updated: Jan 6, 2026

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
08:05

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

10.1K
Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

1.2K
The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
05:40

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans

Published on: April 28, 2022

3.4K

Area of Science:

  • Addiction Medicine
  • Clinical Psychology
  • Public Health

Background:

  • Controlled drinking remains a debated therapy goal for problematic alcohol use, particularly for dependent individuals.
  • Few structured controlled drinking programs have undergone rigorous evaluation.
  • The Alcochoix+ program offers a six-step approach to controlled drinking.

Purpose of the Study:

  • To evaluate the effectiveness of the "Alcochoix+" six-step controlled drinking program.
  • To observe the outcomes for excessive and dependent drinkers participating in the program.
  • To assess changes in drinking habits, Alcohol Use Disorder Identification Test (AUDIT) scores, and quality of life.

Main Methods:

  • A cohort study design was employed across four centers in French-speaking Switzerland.
  • Sixty participants were enrolled between May 2010 and September 2011.
  • Patients were evaluated before and up to one year after program completion, tracking drinking habits and AUDIT scores.

Main Results:

  • Thirty-four participants (56.7%) completed the program, achieving a median weekly alcohol reduction of 160g.
  • The mean AUDIT score decreased by 14.1 points.
  • Improvements in quality of life were observed and remained stable one year post-program, with high participant satisfaction.

Conclusions:

  • The Alcochoix+ program successfully engaged excessive and moderately dependent drinkers.
  • Full program participation led to significant alcohol reduction and modest quality of life improvements.
  • Further research is needed to understand barriers to program integration and the role for moderately dependent drinkers.