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A TRAV26-1-encoded recognition motif focuses the biased T cell response in celiac disease

Rahel Frick1,2, Kristin Støen Gunnarsen1,2, Shiva Dahal-Koirala1,3

  • 1Department of Immunology, University of Oslo and Oslo University Hospital, Oslo, Norway.

European Journal of Immunology
|October 4, 2019
PubMed

The semi-public T-cell response towards the gluten epitope DQ2.5-glia-α2 uses a prototypic TCR encoded by the germline segments TRAV26-1 and TRBV7-2. Through mutagenesis experiments, we show that a TRAV26-1encoded recognition motif contacts the MHC β-chain and the TCR CDR3β loop underpinning this conserved T-cell response restricted to the prototypic TCRs.

Keywords:
Celiac diseaseRepertoire biasTCRTRAV26-1pMHC recognition

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