Association between IL-1B gene polymorphisms and Helicobacter pylori infection: A meta-analysis

Area of Science:

• Genetics and Molecular Biology
• Infectious Diseases
• Gastroenterology

Background:

• Helicobacter pylori (H. pylori) infection is a significant global health concern.
• Interleukin-1 beta (IL-1B) gene polymorphisms are investigated for their potential role in H. pylori infection susceptibility.
• Specific IL-1B gene polymorphisms include IL-1B-511C/T, IL-1B-31C/T, and IL-1B+3954C/T.

Purpose of the Study:

• To conduct a meta-analysis clarifying the impact of IL-1B gene polymorphisms on H. pylori infection risk.
• To evaluate the association between IL-1B-511C/T, IL-1B-31C/T, and IL-1B+3954C/T polymorphisms and H. pylori infection.

Main Methods:

• A comprehensive literature search was performed across multiple databases (PubMed, Web of Science, EMBASE, Cochrane Library, CNKI, Wanfang) until September 2018.
• Odds ratios (OR) and 95% confidence intervals (CIs) were calculated to assess the strength of associations.
• Statistical analyses were performed using STATA 12 software.

Main Results:

• The meta-analysis included 45 articles with 9606 cases and 5654 controls.
• A significant association was found between IL-1B-511C/T polymorphism and an increased risk of H. pylori infection under a recessive model (OR=1.13, 95% CI: 1.00-1.27, P=0.048).
• No significant associations were observed for IL-1B-31C/T and IL-1B+3954C/T polymorphisms with H. pylori infection risk across all models.

Conclusions:

• The IL-1B-511C/T polymorphism is associated with the risk of H. pylori infection.
• Further high-quality studies with larger sample sizes are recommended to confirm these findings.
• The study highlights the genetic predisposition related to IL-1B gene variations in H. pylori infection.