Tailoring a rapid autopsy protocol to explore cancer evolution: a patient collaboration

Area of Science:

• Oncology
• Genomics
• Bioethics

Background:

• Genomic analysis of cancer tissues from rapid autopsy programs has advanced cancer research.
• Such programs are not yet established in New Zealand.
• A neuroendocrine tumour research group, NETwork!, received a patient's post-mortem tissue donation request.

Purpose of the Study:

• To outline the ethical, logistical, and social considerations for accepting a post-mortem tumour tissue donation.
• To highlight the scientific and educational benefits of such donations for cancer research in New Zealand.

Main Methods:

• Review of ethical guidelines and protocols for post-mortem tissue donation.
• Discussion of logistical challenges in tissue preservation and transport.
• Analysis of social implications and patient engagement.

Main Results:

• A comprehensive process for accepting the patient's donation was successfully navigated.
• The donation underscores the potential for valuable cancer research using post-mortem tissues.
• Established protocols can facilitate future donations.

Conclusions:

• Accepting post-mortem tumour donations is feasible and ethically sound.
• Such donations offer significant scientific and educational value for advancing cancer research in New Zealand.
• This case sets a precedent for future tissue procurement.