Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Basic studies on enzyme therapy of immune complex diseases].

C Steffen, J Menzel

    Wiener Klinische Wochenschrift
    |April 12, 1985
    PubMed
    Summary

    Enzymatic treatment shows promise for rheumatoid arthritis and immune complex diseases. Oral enzymes were absorbed and degraded immune complexes, reducing arthritis in animal models, suggesting high-dose daily administration may be effective.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    German guidelines for the diagnosis and treatment of squamous-cell carcinoma and adenocarcinoma of the esophagus-version 4.0.

    ESMO gastrointestinal oncology·2026
    Same author

    Trade-off between resistance and persistence in high cell density cultures.

    mSystems·2025
    Same author

    Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities.

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2023
    Same author

    Removal of patient-specific reconstruction plates after mandible reconstruction with a fibula free flap: is the plate the problem?

    International journal of oral and maxillofacial surgery·2021
    Same author

    Biomechanical comparison of polylactide-based versus titanium miniplates in mandible reconstruction in vitro.

    Journal of stomatology, oral and maxillofacial surgery·2019
    Same author

    Complication rates and clinical outcomes of osseous free flaps: a retrospective comparison of CAD/CAM versus conventional fixation in 128 patients.

    International journal of oral and maxillofacial surgery·2019

    Area of Science:

    • Biochemistry
    • Immunology
    • Pharmacology

    Background:

    • Rheumatoid arthritis (RA) and immune complex diseases involve complex pathological mechanisms.
    • Current treatments for these conditions have limitations, necessitating novel therapeutic strategies.

    Purpose of the Study:

    • To investigate the potential of enzymatic therapy for rheumatoid arthritis and other immune complex diseases.
    • To evaluate the absorption and efficacy of orally administered enzymes in preclinical models.

    Main Methods:

    • In vitro studies involving the incubation of soluble immune complexes with varying enzyme concentrations.
    • Animal experiments in guinea pigs and rabbits to assess the oral absorption of radiolabeled enzymes.
    • Induction of experimental arthritis in rabbits and assessment of therapeutic effects of enzyme administration based on dosage and timing.

    Main Results:

    • Orally administered enzymes were absorbed intact in animal models (guinea pigs, rabbits).
    • Enzymes demonstrated dose-dependent cleavage of soluble immune complexes in vitro.
    • Enzyme treatment significantly inhibited antigen-induced experimental arthritis in rabbits, with efficacy dependent on dosage and administration schedule.

    Conclusions:

    • Oral enzyme administration is a viable approach for treating immune complex diseases.
    • High-dose, daily enzyme administration is favored for therapeutic applications due to limited duration of effect.
    • Enzymatic therapy presents a potential treatment avenue for rheumatoid arthritis and related immune complex disorders.

    Related Experiment Videos