[Creation, implementation and objectives of CARADERM, a national network for rare skin carcinomas - Adnexal neoplasm
A Seris1, M Battistella2, M Beylot-Barry3
1Unité de recherche clinique, hôpital François Mitterrand, 64000 Pau, France.
Introduction:
CARADERM is a French national network that includes patients with rare skin adnexal neoplasms. The present paper describes only the adnexal neoplasm part of this network. The primary objective of CARADERM is to improve medical care for malignant skin adnexal neoplasms. A multidisciplinary review group and a centralized pathological review group have been set up.
Patients And Methods:
A dual network of clinicians and pathologists has been set up. Data are recorded in a secure database.
Results:
The CARADERM network comprises of 38 clinical centres and 22 pathology centres. Between 2014 and 2017, 1598 patients with an adnexal neoplasm were included. Data of interest were documented in 80% of cases. Median patient age was 72 years. Major histological subtypes were sweat gland carcinomas (50%), hair follicle carcinomas (37.7%), and sebaceous gland carcinomas (9.8%). Surgery was the first-line treatment for 81% of patients, including 76.9% with standard surgical margin analysis, and 5.5% with exhaustive margin analysis. 920 patients (57.6%) underwent a national pathology review process.
Discussion:
The CARADERM network aims at providing assistance in difficult situations concerning diagnosis and care in skin adnexal neoplasms. Analysis of the CARADERM data should allow the creation of a prognostic classification of these rare neoplasms together with recommendations. A national multidisciplinary consensus exists. Translational and therapeutic research is ongoing.
Conclusion:
The CARADERM network is currently recruiting and more data should lead to improved knowledge of these tumours in the coming years.
Insights
The CARADERM network has improved care for rare skin adnexal neoplasms by establishing a national registry. This network facilitates diagnosis, treatment, and research for these uncommon tumors.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- CARADERM is a French national network focused on rare skin adnexal neoplasms.
- The network aims to enhance medical care for malignant skin adnexal neoplasms through collaboration.
Purpose of the Study:
- To describe the structure and initial findings of the CARADERM network.
- To establish a foundation for improved diagnosis, care, and research in skin adnexal neoplasms.
Main Methods:
- Establishment of a dual network of clinicians and pathologists.
- Secure data recording in a centralized database.
- Implementation of multidisciplinary and centralized pathological review groups.
Main Results:
- Inclusion of 1598 patients with adnexal neoplasms between 2014-2017 across 38 clinical and 22 pathology centers.
- Major histological subtypes identified: sweat gland (50%), hair follicle (37.7%), and sebaceous gland (9.8%) carcinomas.
- Surgery was the primary treatment (81%), with 57.6% undergoing national pathology review.
Conclusions:
- The CARADERM network provides crucial support for complex cases of skin adnexal neoplasms.
- Data analysis is expected to yield a prognostic classification and clinical recommendations.
- Ongoing research and recruitment promise enhanced understanding of these rare tumors.
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