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Related Concept Videos

Endoscopic Procedures V: ERCP01:26

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Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Related Experiment Video

Updated: Jan 6, 2026

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
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Does rectal ketoprofen prevent post ERCP pancreatitis?

Elias Makhoul1, Joe El Mir1, Marc Harb1

  • 1Department of Gastroenterology, University Hospital of Notre Dame De Secours Byblos, Faculty of Medicine and Sciences, Holy Spirit University of Kaslik, Lebanon.

Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology
|October 5, 2019
PubMed
Summary
This summary is machine-generated.

Rectal ketoprofen did not significantly prevent post-ERCP pancreatitis (PEP). This study found no difference in PEP rates between patients receiving rectal ketoprofen and those in the control group, indicating it

Keywords:
ERCPKetoprofenPancreatitis

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Area of Science:

  • Gastroenterology
  • Clinical Trials
  • Pharmacology

Background:

  • Acute pancreatitis is a common complication of Endoscopic Retrograde Cholangiopancreatography (ERCP).
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are investigated for prophylaxis against post-ERCP pancreatitis (PEP).
  • Limited data exists on the efficacy of rectal ketoprofen for PEP prevention.

Purpose of the Study:

  • To evaluate the effectiveness of prophylactic rectal ketoprofen in reducing the incidence of PEP.
  • To assess if rectal ketoprofen can mitigate the risk of pancreatitis following ERCP procedures.

Main Methods:

  • A non-randomized, retrospective, single-center study.
  • 242 patients undergoing ERCP were divided into a control group and a trial group.
  • The trial group received 100 mg of rectal ketoprofen 30 minutes before ERCP.

Main Results:

  • The overall incidence of PEP was 6%.
  • PEP occurred in 5 patients in the ketoprofen group and 9 in the control group.
  • Statistical analysis revealed no significant difference in PEP prevalence between the groups.

Conclusions:

  • Prophylactic administration of rectal ketoprofen before ERCP is not effective in preventing post-ERCP pancreatitis.
  • The study suggests that rectal ketoprofen does not offer a protective benefit against PEP.