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Updated: Jan 6, 2026

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
Published on: April 1, 2019
[Trachea-carinal Resection, Reconstruction and Bronchoplasty]
1Department of Thoracic Surgery, The University of Tokyo, Tokyo, Japan.
Abstract:
Locally advanced lung cancer invading central bronchi, carina, and trachea can be resected with bronchoplastic techniques including sleeve lobectomy and sleeve pneumonectomy. These procedures can be performed on selected patients with advanced lung cancer invading the root of lobar bronchus or carina. After the bronchial/tracheal resection, anastomosis of the severed bronchus/trachea is done to reconstruct the airway. The anastomosis should be done with great care, avoiding postoperative dehiscence, stenosis, or granulation formation. Some tips and pitfalls of the procedures, including determination of the bronchial cutting line, detail of the suturing, methods for bronchial mobilization, and anastomotic coverage are described. Guidelines in our country or oversees recommend that lung-sparing anatomic resection (sleeve lobectomy) may be preferred over pneumonectomy for cardiopulmonary reserve of the patient.
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