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Updated: Jan 6, 2026

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
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Published on: May 22, 2019

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X-chromosome upregulation is driven by increased burst frequency

Anton J M Larsson1, Christos Coucoravas2, Rickard Sandberg1

  • 1Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.

Nature Structural & Molecular Biology
|October 5, 2019
PubMed
Summary

X-chromosome upregulation compensates for gene dosage imbalance by increasing transcription burst frequency. This mechanism is established during X inactivation in differentiating female cells, providing key mechanistic insights.

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