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Acne fulminans with osteolytic lesions.

P Nault, M Lassonde, P St-Antoine

    Archives of Dermatology
    |May 1, 1985
    PubMed
    Summary

    Severe acne, known as acne fulminans, can cause rare bone lesions. Propionibacterium acnes was found in bone tissue, suggesting a link between this bacteria and osteolytic lesions. Corticosteroids show promise for treatment.

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    Area of Science:

    • Dermatology
    • Orthopedics
    • Infectious Diseases

    Background:

    • Acne fulminans is a rare, severe form of acne characterized by sudden onset of nodular, ulcerative acne.
    • Osteolytic bone lesions are typically associated with metastatic cancer or primary bone tumors.

    Observation:

    • A patient with severe acne fulminans presented with multifocal lytic bone lesions.
    • Propionibacterium acnes was successfully isolated from bone tissue samples.

    Findings:

    • This case highlights a rare association between acne fulminans and osteolytic bone lesions.
    • The presence of Propionibacterium acnes in bone suggests a potential role in the pathophysiology of these lesions.

    Implications:

    • The pathophysiology linking acne fulminans and osteolytic bone lesions remains unclear.
    • Systemic corticosteroids combined with local treatments appear effective in managing this rare condition.
    • Further research is warranted to elucidate the mechanism and optimize therapeutic strategies.

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