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Published on: February 28, 2012
Alcohol-related acute atrial fibrillation. A case-control study and review of 40 patients
Insights
Heavy alcohol use is linked to acute atrial fibrillation. Alcohol withdrawal syndrome may increase the risk of developing this heart rhythm disorder.
Area of Science:
- Cardiology
- Internal Medicine
- Addiction Medicine
Background:
- Heavy alcohol consumption is a common issue.
- Acute atrial fibrillation is a prevalent cardiac arrhythmia.
- A direct link between heavy alcohol use and acute atrial fibrillation has not been previously established.
Purpose of the Study:
- To investigate the association between heavy alcohol use and idiopathic acute atrial fibrillation.
- To determine if alcohol withdrawal syndrome is a risk factor for alcohol-related atrial fibrillation.
Main Methods:
- Retrospective case-control study.
- Involved 64 patients with idiopathic acute atrial fibrillation and 64 matched controls.
- Data collected from general medical admissions, focusing on alcohol use documentation.
Main Results:
- 62% of acute atrial fibrillation cases were heavy alcohol users, compared to 33% of controls.
- Patients with alcohol-related atrial fibrillation were more likely to show alcohol withdrawal syndrome.
- No significant differences were observed in heart failure, ECG abnormalities, cardiomegaly, or electrolyte disturbances between groups.
Conclusions:
- Heavy alcohol use is a significant potential cause of acute atrial fibrillation.
- Alcohol withdrawal syndrome may be a specific risk factor for developing alcohol-related atrial fibrillation.
- Further research is warranted to elucidate the mechanisms involved.
Abstract:
Heavy alcohol use has been suspected to cause acute atrial fibrillation, but an association between these two common problems has never been demonstrated. We retrospectively reviewed 64 cases with idiopathic acute atrial fibrillation and 64 age- and sex-matched controls, randomly selected from among general medical admissions. Sixty-two percent of cases and 33% of controls had documentation as heavy users of alcohol. Furthermore, patients with alcohol-related atrial fibrillation were significantly more likely to manifest alcohol withdrawal syndrome than were other inpatients with heavy alcohol use. Patients with alcohol-related acute atrial fibrillation were not different from other patients with acute atrial fibrillation with respect to clinical evidence of congestive heart failure, electrocardiographic abnormalities, cardiomegaly, electrolyte disturbance, or response to therapy. Heavy alcohol use is an important potential etiology for acute atrial fibrillation; alcohol withdrawal may represent a particular risk for such alcohol-related atrial fibrillation.
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