Related Experiment Video
Updated: Jan 6, 2026
11:14
Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
58.7K
Impact of Molybdenum Compounds as Anticancer Agents
Ayodele T Odularu1, Peter A Ajibade2, Johannes Z Mbese1
1Department of Chemistry, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.
Bioinorganic Chemistry and Applications
|October 5, 2019
Summary
Molybdenum compounds show promise in controlling cancer, advancing from inorganic forms to nanoparticles. Their application in nanofibrous supports, combination therapy, and biosensors offers new strategies for esophageal and breast cancer treatment.
Area of Science:
- Medicinal Chemistry
- Nanotechnology
- Oncology
Background:
- Molybdenum compounds are increasingly investigated for their therapeutic potential in cancer treatment.
- The evolution of molybdenum-based agents spans from simple inorganic compounds to complex organometallic structures and nanoparticles.
Purpose of the Study:
- To review the progress and applications of molybdenum compounds as anticancer agents.
- To highlight the role of molybdenum in controlling esophageal and breast cancers.
Main Methods:
- Literature review of inorganic molybdenum compounds, organomolybdenum complexes, and molybdenum nanoparticles.
- Analysis of molybdenum compounds integrated with nanofibrous materials.
- Survey of combination therapy and biosensor applications.
Main Results:
- Molybdenum compounds demonstrate efficacy as anticancer agents, particularly when supported by nanofibrous materials with specific physicochemical properties.
- Combination therapy approaches utilizing molybdenum compounds show synergistic effects.
- Molybdenum-based biosensors offer potential for cancer biomarker detection.
Conclusions:
- Molybdenum compounds represent a versatile platform for developing novel anticancer strategies.
- Nanotechnology integration, combination therapies, and biosensor development are key areas for future research in molybdenum-based cancer interventions.
Related Concept Videos
01:15Drugs that Stabilize Microtubules
2.6K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.6K
01:10Drugs that Destabilize Microtubules
3.6K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
3.6K
01:46Electron Transport Chain: Complex I and II
18.3K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
18.3K
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
01:25Mutagenicity and Carcinogenicity
1.8K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.8K