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Updated: Jan 6, 2026
Merkel Cell Polyomavirus Infection and Detection
Published on: February 7, 2019
Brain metastasis of Merkel cell carcinoma - A rare case report
Ricardo Lourenço Caramanti1, Feres Eduardo Chaddad Neto2, Lucas Crociati Meguins1
1Department of Neurosurgery, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil.
Background:
Merkel cell carcinoma (MCC) is a rare neuroendocrine skin tumor. In our knowledge, only 30 cases of brain metastasis were reported in literature. The authors report a case of 57-year-old male with elevated intracranial pressure signs, which a frontal mass with pathological diagnosis of MCC.
Case Description:
A 57-year-old male was admitted with a 3-month history of progressive headache, associated with nausea and dizziness. The magnetic resonance imaging showed a left frontal lobe, parasagittal, and nodular lesion with perilesional edema. The patient underwent complete surgical resection with success. The adjuvant treatment was radiotherapy and chemotherapy.
Conclusion:
In our knowledge, there is a little number of cases of MCC reported in literature. Surgical management is considered in cases with intracranial hypertension or focal signs. The adjuvant treatment options are immunotherapy and radiotherapy.
