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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Current methods and challenges for acute pain clinical trials.

Ian Gilron^1,2, Daniel B Carr³, Paul J Desjardins⁴

¹Departments of Anesthesiology and Perioperative Medicine and.

|October 5, 2019

Summary

This review discusses improving clinical trial methods for acute pain treatments. Future trials should minimize bias and measure relevant outcomes, especially for high-risk patients.

Keywords:

Acute pain Analgesic trial Clinical trial

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Last Updated: Jan 6, 2026

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Published on: December 19, 2016

Area of Science:

Pain Management
Clinical Trial Methodology
Pharmacology

Background:

Acute pain management has historically driven the development of analgesic clinical trial methods.
Understanding patient variability and pain responses is crucial for effective treatment.

Purpose of the Study:

To review current methods and challenges in acute pain clinical trials.
To provide recommendations for future trial design and conduct.

Main Methods:

Literature review of existing acute pain clinical trial methodologies.
Analysis of challenges and emerging needs in the field.

Main Results:

Growing knowledge highlights the need for early-phase trial designs that minimize variability and enhance assay sensitivity.
Minimizing bias through blinding and randomization is essential.
Measuring clinically relevant outcomes, such as movement-evoked pain, is increasingly important.

Conclusions:

Further improvements are needed, particularly in trial methods for complex patients at high risk of severe acute pain.
Future research should focus on optimizing trial designs to better capture treatment effects in diverse acute pain populations.