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Updated: Jan 6, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
New concepts in C. difficile management
1Nottingham Digestive Diseases Centre, Queen's Medical Centre, Nottingham, UK.
Background:
Clostridium difficile infection is transmitted via spores, and the disease is mediated via secreted toxins. It represents a significant healthcare problem, and clinical presentation can range from asymptomatic carriage to life-threatening pseudomembranous colitis.
Sources Of Data:
publications in the field, with a focus on recent developments and concepts.
Areas Of Agreement:
infection control measures, antibiotic stewardship and current management of the initial episode of C. difficile infection.
Areas Of Controversy:
selection and sequence of interventions for the management of recurrent C. difficile infection; management of persistent carriers of toxigenic C. difficile in patients at high risk of subsequent C. difficile infection.
Growing Points:
use of faecal microbiota transplantation for recurrent C. difficile infection.
Areas Timely For Developing Research:
role of specific microbiota-mediated interventions and vaccination in the treatment and prevention of C. difficile infection.
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