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Updated: Jan 6, 2026
11:22
Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay
Published on: August 26, 2018
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Alternative splicing in Alzheimer's disease.
Giuseppe Biamonti1, Angela Amato2, Elisa Belloni2
1Istituto di Genetica Molecolare "Luigi Luca Cavalli-Sforza", Consiglio Nazionale delle Ricerche (IGM-CNR), via Abbiategrasso, 207, 27100, Pavia, Italy. giuseppe.biamonti@igm.cnr.it.
Aging Clinical and Experimental Research
|October 5, 2019
Summary
Alzheimer's disease (AD) involves gene expression changes due to alternative splicing (AS) abnormalities. This review explores how AS contributes to AD pathogenesis and discusses new therapeutic strategies targeting these splicing alterations.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Alzheimer's disease (AD) is a prevalent neurodegenerative disorder in older adults.
- The precise molecular mechanisms underlying AD remain incompletely understood.
- Alternative splicing (AS) is increasingly recognized for its role in gene expression reprogramming in AD.
Purpose of the Study:
- To review the current understanding of how altered alternative splicing contributes to Alzheimer's disease pathogenesis.
- To discuss recent therapeutic strategies aimed at correcting aberrant AS in AD.
Main Methods:
- Literature review of studies on alternative splicing in Alzheimer's disease.
- Analysis of molecular mechanisms linking splicing abnormalities to AD pathology.
- Overview of emerging therapeutic targets and approaches.
Main Results:
- Splicing abnormalities in AD tissues are linked to mutations in regulatory sequences and altered splicing factors.
- These splicing alterations may influence the onset and progression of Alzheimer's disease.
- Aberrant AS regulation presents potential therapeutic targets for AD intervention.
Conclusions:
- Alternative splicing plays a significant role in the molecular pathology of Alzheimer's disease.
- Targeting aberrant AS offers a promising avenue for developing novel AD therapies.
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