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Hashimoto Thyroiditis in Primary Thyroid Non-Hodgkin Lymphoma.

Antonio Travaglino1, Mirella Pace1, Silvia Varricchio1

  • 1Department of Advanced Biomedical Sciences, Pathology Section, University of Naples "Federico II", Naples, Italy.

American Journal of Clinical Pathology
|October 5, 2019
PubMed
Summary

Most patients with primary thyroid lymphoma (PTL) have evidence of Hashimoto thyroiditis (HT). HT prevalence is higher in mucosa-associated lymphoid tissue (MALT) lymphoma than diffuse large B-cell lymphoma (DLBCL).

Keywords:
HashimotoLymphomaMALTThyroidThyroiditis

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Area of Science:

  • Endocrinology
  • Oncology
  • Immunology

Background:

  • Hashimoto thyroiditis (HT) is an autoimmune thyroid disease.
  • Primary thyroid lymphoma (PTL) can arise in the thyroid gland.
  • The relationship between HT and PTL requires further investigation.

Purpose of the Study:

  • To determine the prevalence of Hashimoto thyroiditis (HT) in patients with primary thyroid lymphoma (PTL).
  • To compare HT prevalence between mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBCL) subtypes of PTL.

Main Methods:

  • A systematic review and meta-analysis of electronic databases was conducted.
  • Studies assessing HT prevalence in PTL using serological markers, clinical history, or histopathology were included.
  • Pooled prevalence of HT and its association with PTL histotype were calculated.

Main Results:

  • Thirty-eight studies comprising 1,346 PTL cases were analyzed.
  • The overall pooled prevalence of any HT evidence in PTL was 78.9%.
  • HT prevalence was significantly higher in MALT lymphoma (P = .007) and mixed DLBCL/MALT lymphoma (P = .002) compared to pure DLBCL.

Conclusions:

  • A high prevalence of Hashimoto thyroiditis (HT) is observed in primary thyroid lymphoma (PTL).
  • The differing prevalence of HT between PTL subtypes suggests distinct pathogenetic origins.
  • A significant proportion of PTL cases with HT may not be adequately monitored clinically.