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Related Experiment Video

Updated: Jan 6, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Correlation between kidney and peripheral nerve functions in Type 2 diabetes.

Y-R Lai1,2,3, B-C Cheng1,4, C-C Huang3

  • 1From the Department of Biological Science, National Sun Yat-Sen University, Kaohsiung.

QJM : Monthly Journal of the Association of Physicians
|October 5, 2019
PubMed
Summary

Kidney function significantly impacts peripheral nerve health in Type 2 diabetes patients. Lower estimated glomerular filtration rate (eGFR) and higher urine albumin-creatinine ratio (UACR) correlate with increased peripheral neuropathy (PN) severity.

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Area of Science:

  • Nephrology
  • Neurology
  • Endocrinology

Background:

  • Limited data exists on the relationship between kidney function and peripheral nerve function in Type 2 diabetes.
  • Peripheral nerve function impairments are often associated with reduced kidney function.

Purpose of the Study:

  • To investigate the impact of peripheral nerve function in Type 2 diabetes patients across different stages of chronic kidney disease (CKD).

Main Methods:

  • A prospective study included 238 Type 2 diabetes patients.
  • Composite amplitude scores of nerve conductions (CAS) measured peripheral neuropathy (PN) severity.
  • Estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) were used to stage CKD.

Main Results:

  • Lower eGFR and higher UACR were linked to older age, longer diabetes duration, and higher rates of retinopathy and PN.
  • Diabetes duration and eGFR were independent predictors of CAS.
  • A critical eGFR threshold of 65.3 ml/min/1.73 m2 was identified for the presence of PN.

Conclusions:

  • A strong correlation exists between kidney function severity and peripheral nerve function in diabetic patients.
  • Patients with eGFR < 65.3 ml/min/1.73 m2 or UACR > 98.6 mg/dl require careful monitoring for PN, even if asymptomatic.