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Histone deposition promotes recombination-dependent replication at arrested forks

Julien Hardy1,2,3, Dingli Dai1,2,3, Anissia Ait Saada1,2,3

  • 1Institut Curie, PSL Research University, UMR3348, Orsay, France.

Plos Genetics
|October 5, 2019
PubMed
Summary

Histone deposition, facilitated by CAF-1 and Asf1, aids Recombination-Dependent Replication (RDR) by stabilizing DNA joint-molecules. This process, occurring downstream of Rad52, enhances cell survival under replication stress.

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