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The relationship between white matter hyperintensities and cognitive reference abilities across the life span

Ana R Moura1, Seonjoo Lee2, Christian Habeck3

  • 1Cognitive Neuroscience Division, The Taub Institute for Research on Aging and Alzheimer's Disease, Columbia University, New York, NY, USA; Departamento de Psiquiatria e Saúde Mental, Centro Hospitalar Lisboa Ocidental, Lisboa, Portugal.

Neurobiology of Aging
|October 5, 2019
PubMed
Summary

White matter hyperintensities (WMH) increase after age 43, negatively impacting cognitive functions like memory and perceptual speed. Parietal lobe WMH burden significantly mediates age-related declines in perceptual speed.

Keywords:
Adult lifespanCognitive agingMRIWhite matter hyperintensities

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