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Sweet Control: MicroRNA Regulation of the Glycome

Chu T Thu1, Lara K Mahal1

  • 1Biomedical Chemistry Institute, Department of Chemistry, New York University, New York, New York 10003, United States.

Biochemistry
|October 6, 2019
PubMed

Insights

MicroRNAs (miRNAs) critically regulate glycosylation, a key biological system. Understanding this miRNA-glycome interaction offers new insights into disease mechanisms and the function of glycosylation enzymes.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Systems Biology

Background:

  • Glycosylation is a complex biological process controlling cellular functions.
  • Aberrant glycosylation is linked to major modern diseases.
  • MicroRNAs (miRNAs) have emerged as key regulators of gene expression.

Purpose of the Study:

  • To review the current literature on miRNA regulation of glycosylation.
  • To explore the connection between miRNAs and the glycome.
  • To identify potential new methods for understanding glycosylation enzymes.

Main Methods:

  • Literature review of studies on miRNA and glycosylation.
  • Analysis of regulatory mechanisms.
  • Synthesis of findings on glycome regulation by miRNAs.

Main Results:

  • miRNAs are confirmed as critical regulators of the glycome.
  • Specific miRNAs influence glycosylation pathways.
  • The interplay between miRNAs and glycosylation enzymes is highlighted.

Conclusions:

  • miRNA regulation is integral to glycosylation processes.
  • This regulatory axis is relevant to understanding disease.
  • Further research into miRNA-glycome interactions can elucidate glycosylation enzyme function.

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