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Mechanical Point Loading Induces Cortex Stiffening and Actin Reorganization.

Jinrong Hu1, Shenbao Chen1, Wenhui Hu2

  • 1Center of Biomechanics and Bioengineering, Key Laboratory of Microgravity (National Microgravity Laboratory), Beijing Key Laboratory of Engineered Construction and Mechanobiology, and CAS Center for Excellence in Complex System Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China; School of Engineering Science, University of Chinese Academy of Sciences, Beijing, China.

Biophysical Journal
|October 6, 2019
PubMed
Summary

Localized cell loading stiffens the cell surface, protecting the nucleus from stress. Increased force and duration amplify cytoskeleton reorganization, revealing rapid actin dynamics in response to mechanical stimuli.

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