Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune studies in oral contraceptive users.

B A Ramalakshmi, V Jagadeesan, K Prema

    Contraception
    |October 1, 1979
    PubMed
    Summary

    Oral contraceptive (OC) use in Indian women did not affect B and T lymphocyte subpopulations or PHA-induced lymphocyte transformation. However, total hemolytic complement (CH50) levels were significantly lower in OC users compared to controls.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Maternal Nutrition, Body Composition and Gestational Weight Gain on Low Birth Weight and Small for Gestational Age-A Cohort Study in an Indian Urban Slum.

    Children (Basel, Switzerland)·2022
    Same author

    Clinical grading of lingual lesions in vitamin B-complex deficiency. 1980.

    The Indian journal of medical research·2013
    Same author

    Pre-clinical toxicity & immunobiological evaluation of DNA rabies vaccine & combination rabies vaccine in rhesus monkeys (Macaca mulatta).

    The Indian journal of medical research·2013
    Same author

    Serum dehydroepiandrosterone and lipid peroxides in human volunteers of different age groups.

    Indian journal of clinical biochemistry : IJCB·2012
    Same author

    Effect of chlorination on the development of marine biofilms dominated by diatoms.

    Biofouling·2011
    Same author

    Prevalence of specific IGM due to toxoplasma, rubella, CMV and c.trachomatis infections during pregnancy.

    Indian journal of medical microbiology·2007

    Area of Science:

    • Immunology
    • Pharmacology
    • Public Health

    Background:

    • Estrogen-progestogen combination oral contraceptives (OCs) are widely used globally.
    • Understanding the immunological effects of OCs is crucial for assessing their safety and impact on health.
    • Previous research on OC effects on the immune system has yielded varied results.

    Purpose of the Study:

    • To investigate the impact of oral contraceptive use on specific immune parameters in Indian women.
    • To compare B and T lymphocyte subpopulations, PHA-induced lymphocyte transformation, and total hemolytic complement levels between OC users and a control group.

    Main Methods:

    • Study population: Indian women from a low-income group.
    • Immune parameters assessed: Percentage of B and T lymphocyte subpopulations, PHA-induced lymphocyte transformation (PILT) using 3H-thymidine incorporation, and total hemolytic complement (CH50) levels.
    Keywords:
    Age FactorsAsiaBiologyClinical ResearchContraceptionContraceptive MethodsDeveloping CountriesEconomic FactorsFamily PlanningImmunityImmunological EffectsIndiaOral ContraceptivesOral Contraceptives, CombinedPhysiologyPopulation CharacteristicsResearch MethodologySocioeconomic FactorsSocioeconomic StatusSouthern Asia

    Related Experiment Videos

  • Comparison: OC users versus a control group.

    • Main Results:

    • No significant differences were observed in the percentage of B and T lymphocyte subpopulations between OC users and the control group.
    • PHA-induced lymphocyte transformation (PILT) levels were comparable between the two groups.
    • Total hemolytic complement (CH50) levels were significantly lower in women using oral contraceptives.

    Conclusions:

    • Oral contraceptive use in this cohort was associated with a depression in circulating complement levels.
    • The observed decrease in CH50 suggests potential alterations in the complement system and circulating immune complexes in OC users.
    • Further research is warranted to elucidate the clinical significance of these findings.