Hyperoside exerts potent anticancer activity in skin cancer

Area of Science:

• Natural Products Chemistry
• Oncology
• Dermatology

Background:

• Hyperoside (Quercetin-3-O-β-D-galactopyranoside) is a flavonol glycoside found in plants like Hypericum and Crataegus.
• It possesses known anti-cancer, anti-inflammatory, and anti-oxidant properties.

Purpose of the Study:

• To investigate the therapeutic potential of hyperoside in skin cancer.
• To evaluate its effects on skin cancer cell lines and chemically induced skin tumors in vivo.

Main Methods:

• In vitro studies on skin cancer cell lines treated with hyperoside.
• In vivo studies using DMBA/TPA induced skin tumors in mice.
• Analysis of key signaling pathways including PI3K/Akt/mTOR, p38 MAPK, and AMPK.

Main Results:

• Hyperoside inhibited proliferation and induced apoptosis and autophagy in cancer cells.
• It modulated the PI3K/Akt/mTOR/p38 MAPK axis and activated AMPK signaling.
• In vivo, hyperoside reduced epidermal hyperplasia, tumor burden, and altered phosphorylation of key signaling proteins.

Conclusions:

• Hyperoside demonstrates significant anti-cancer effects in both in vitro and in vivo models of skin cancer.
• Its mechanism involves the modulation of critical cellular signaling pathways.
• Hyperoside may hold therapeutic value for the chemoprevention of skin cancer.