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The in-vitro activity of some antimicrobial agents against methicillin-resistant Staphylococcus aureus
The Journal of Antimicrobial Chemotherapy
|March 1, 1985
Abstract:
A total of 185 strains of methicillin resistant Staphylococcus aureus was investigated for sensitivity to five other antimicrobial agents. The vast majority of these strains were also resistant to gentamicin and fusidic acid. Rifampicin was the most active drug tested (MIC90, 0.007 mg/l), while two newer compounds teichomycin and ciprofloxacin showed equal and appreciable activity (MIC90, 0.5 mg/l).
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) strains show high resistance to gentamicin and fusidic acid. Rifampicin demonstrated the highest activity against these MRSA strains, followed by teichomycin and ciprofloxacin.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Methicillin-resistant Staphylococcus aureus (MRSA) is a significant public health concern.
- High rates of resistance to common antibiotics necessitate the evaluation of alternative treatments.
Purpose of the Study:
- To assess the antimicrobial susceptibility of 185 MRSA strains.
- To determine the efficacy of rifampicin, teichomycin, and ciprofloxacin against MRSA.
Main Methods:
- Phenotypic characterization of 185 MRSA isolates.
- Antimicrobial susceptibility testing using standard methods.
- Determination of Minimum Inhibitory Concentrations (MIC90) for selected agents.
Main Results:
- The majority of MRSA strains exhibited resistance to gentamicin and fusidic acid.
- Rifampicin displayed potent activity with a low MIC90 of 0.007 mg/l.
- Teichomycin and ciprofloxacin showed comparable and significant activity (MIC90, 0.5 mg/l).
Conclusions:
- Rifampicin is a highly effective agent against the studied MRSA strains.
- Teichomycin and ciprofloxacin represent promising therapeutic options for MRSA infections.
- Continued surveillance of antimicrobial resistance patterns is crucial for effective treatment strategies.