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Related Concept Videos

Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Methods of Documentation VI: Case Management Model01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Dosage Regimen: Individualization01:24

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Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
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Dosage Regimen Designs: Nomograms and Tabulations01:23

Dosage Regimen Designs: Nomograms and Tabulations

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Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
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Drug Dosage Regimen: Overview01:15

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A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
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Characterization of changes in medication complexity using a modified scoring tool.

Andrea Sikora Newsome1, Daniel Anderson2, Morgan E Gwynn3

  • 1College of Pharmacy, University of Georgia, Augusta, GA, and Department of Pharmacy, Augusta University Medical Center, Augusta, GA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|October 6, 2019
PubMed
Summary
This summary is machine-generated.

Medication regimen complexity in critically ill adults changes significantly over time, peaking at 24 hours post-admission. A modified 17-item tool (mMRC-ICU) effectively tracks these changes, aiding in pharmacist resource allocation.

Keywords:
critical caredrug therapypatient safetypatientspharmacistspharmacypharmacy practice modelscoring tool

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Area of Science:

  • Pharmacology
  • Critical Care Medicine
  • Health Services Research

Background:

  • Medication regimen complexity is a significant factor in intensive care units (ICUs).
  • Existing tools for measuring complexity, like the Medication Regimen Complexity-Intensive Care Unit (MRC-ICU) tool, can be lengthy.
  • Understanding dynamic changes in complexity is crucial for patient care and resource management.

Purpose of the Study:

  • To characterize dynamic changes in medication regimen complexity in critically ill adults.
  • To validate a modified, shorter version of the MRC-ICU scoring tool (mMRC-ICU).
  • To explore the relationship between medication complexity and patient outcomes.

Main Methods:

  • A retrospective observational chart review of 130 adult patients admitted to a medical ICU.
  • Assessment of medication regimen complexity using the 39-item MRC-ICU tool and a modified 17-item mMRC-ICU tool.
  • Validation of the mMRC-ICU by correlating scores with the MRC-ICU, patient acuity, ICU length of stay (LOS), and inpatient mortality.

Main Results:

  • Significant dynamic changes in medication regimen complexity were observed over time.
  • The highest complexity scores were recorded at 24 hours after ICU admission.
  • The modified mMRC-ICU tool demonstrated validity in assessing complexity and its correlation with patient outcomes.

Conclusions:

  • The modified MRC-ICU (mMRC-ICU) tool provides a valid and potentially more efficient method for assessing medication regimen complexity in ICUs.
  • Changes in medication complexity over time offer insights into pharmacist workload and resource needs.
  • Further external validation of the MRC-ICU and mMRC-ICU tools in diverse critically ill populations is warranted.