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Updated: Jan 6, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Comparison of Usefulness of Cardiac Resynchronization Therapy in Patients With Type 1 Myotonic Dystrophy With Versus

Anish Nikhanj1, Soori Sivakumaran1, Haran Yogasundaram1

  • 1Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.

The American Journal of Cardiology
|October 7, 2019
PubMed

Insights

Cardiac resynchronization therapy improves heart function in type 1 myotonic dystrophy patients with left bundle branch block. This treatment effectively reduces QRS duration and enhances left ventricular ejection fraction in this patient group.

Area of Science:

  • Cardiology
  • Neuromuscular Disorders
  • Medical Devices

Background:

  • Type 1 myotonic dystrophy (DM1) patients often exhibit cardiac abnormalities, including arrhythmias and conduction delays.
  • Left bundle branch block (LBBB) in DM1 is associated with impaired left ventricular (LV) systolic function due to electromechanical dyssynchrony.

Purpose of the Study:

  • To evaluate the feasibility and effectiveness of cardiac resynchronization therapy (CRT) in DM1 patients with LBBB and reduced LV systolic function.

Main Methods:

  • Prospective study of 64 DM1 patients.
  • Analysis of 12 patients (19%) with LBBB.
  • Eight patients received CRT devices; outcomes including QRS duration and LV ejection fraction (LVEF) were assessed.

Main Results:

  • CRT implantation in DM1 patients with LBBB was feasible.
  • Median QRS duration decreased from 173 ms to 166 ms (p=0.04).
  • Median LVEF improved significantly from 37% to 46% (p=0.007).

Conclusions:

  • Cardiac resynchronization therapy is a viable and effective treatment for advanced cardiac disease in DM1 patients with LBBB.
  • CRT improves LV systolic function and reduces electromechanical dyssynchrony in this vulnerable population.

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