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Related Concept Videos

Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Related Experiment Video

Updated: Jan 6, 2026

Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
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Modelling collective cell migration: neural crest as a model paradigm.

Rasa Giniūnaitė1, Ruth E Baker2, Paul M Kulesa3

  • 1Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Woodstock Road, Oxford, OX2 6GG, UK. rasa.giniunaite@maths.ox.ac.uk.

Journal of Mathematical Biology
|October 7, 2019
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Summary

Mathematical models aid in understanding collective cell migration, including neural crest cell movement. This review explores various modeling approaches and their biological insights.

Keywords:
Collective cell migrationDomain growthIndividual-based modelsNeural crestPartial differential equations

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Area of Science:

  • Mathematical Biology
  • Developmental Biology
  • Cell Biology

Background:

  • Collective cell migration is crucial in development and disease.
  • Numerous mathematical models exist to study cell migration.
  • Key factors include cell-cell and cell-tissue interactions, and domain growth.

Purpose of the Study:

  • To review mathematical modeling approaches for collective cell migration.
  • To highlight applications in neural crest cell migration.
  • To discuss the relationship between microscale and macroscale models.

Main Methods:

  • Review of existing mathematical modeling techniques.
  • Analysis of factors influencing cell migration.
  • Case study of neural crest cell migration.

Main Results:

  • Different modeling approaches offer complementary strengths.
  • Integrating models with experimental data yields biological insights.
  • Understanding model relationships is important.

Conclusions:

  • Mathematical modeling, combined with experiments, advances understanding of neural crest cell migration.
  • Future challenges exist in refining these models.
  • This interdisciplinary approach provides valuable biological insights.