Related Experiment Video

Updated: Jan 6, 2026

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
09:14

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

11.4K

Vaccines against human respiratory syncytial virus in clinical trials, where are we now?

Iebe Rossey1,2, Xavier Saelens1,2

  • 1VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.

Expert Review of Vaccines
|October 8, 2019
PubMed

Insights

Developing a safe human respiratory syncytial virus (RSV) vaccine is crucial due to high global mortality. This review examines challenges and promising vaccine candidates in clinical trials for RSV prevention.

Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Background:

  • Human respiratory syncytial virus (RSV) causes significant global morbidity and mortality, particularly in young children and the elderly.
  • Despite its impact, developing an effective RSV vaccine faces hurdles including a history of trial failures, challenging target demographics, and incomplete understanding of protective immunity.

Purpose of the Study:

  • To review the challenges in developing an effective human respiratory syncytial virus (RSV) vaccine.
  • To discuss current RSV vaccine candidates in clinical trials and their strategies for overcoming development obstacles.

Main Methods:

  • Review of live-attenuated, vectored, subunit, and particle-based vaccine approaches for RSV.
  • Analysis of approximately 30 RSV vaccine candidates currently in clinical evaluation.

Main Results:

  • Multiple vaccine formats are under investigation, with several promising candidates progressing through clinical trials.
  • Ongoing research addresses historical challenges, including vaccine safety, immunogenicity, and identifying correlates of protection.

Conclusions:

  • The field of RSV vaccine development is advancing rapidly, with potential for near-term clinical implementation.
  • Several promising RSV vaccine candidates offer hope for a safe and effective preventative measure against this significant respiratory pathogen.

Keywords:
Live-attenuated vaccinesparticle-based vaccinesrespiratory syncytial virussubunit vaccinesvectored vaccines

More Related Videos

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.2K
Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

16.9K

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.5K
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.1K
Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
1.2K
Vaccinations01:51

Vaccinations

Overview
51.1K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
974
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
995