Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Non-nuclear Inheritance

Non-nuclear Inheritance

Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.

Inheritance

Inheritance

Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype...

Chromosomal Theory of Inheritance

Chromosomal Theory of Inheritance

In 1866, Gregor Mendel published the results of his pea plant breeding experiments, providing evidence for predictable patterns in the inheritance of physical characteristics. The significance of his findings was not immediately recognized. In fact, the existence of genes was unknown at the time. Mendel referred to hereditary units as “factors.”

Pedigree Analysis

Pedigree Analysis

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Inheritance of Chromatin Structures

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fumarate Hydratase-deficient Renal Cell Carcinoma - A Multicentric Comprehensive Clinical, Pathological, and Molecular Analysis of 12 Cases.

Pathobiology : journal of immunopathology, molecular and cellular biology·2026

Same author

Premedication with steroids in breast cancer - supportive treatment or tumour growth promotion?

Magyar onkologia·2026

Same author

[Successful selpercatinib treatment of metastatic medullary thyroid cancer carrying rare RET variant].

Magyar onkologia·2026

Same author

DNA methylation and demethylation dynamics in pituitary neuroendocrine tumours.

Endocrine-related cancer·2026

Same author

Familial medullary thyroid carcinoma secondary to an <i>SLC30A9</i> intragenic deletion and translation reinitiation.

medRxiv : the preprint server for health sciences·2026

Same author

[Comorbidities affecting abiraterone treatment in patients with metastatic castration-resistant prostate cancer: a meta- analysis].

Magyar onkologia·2026

Search research articles

Related Experiment Video

Updated: Jan 6, 2026

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

Published on: August 8, 2017

Brief Description of Inheritance Patterns.

Annamária Kövesdi^1,2, Attila Patócs^3,4,5

¹Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

Experientia Supplementum (2012)

|October 8, 2019

Summary

Human genetics is crucial in medicine, with germline DNA variants influencing disease transmission. This chapter reviews classical inheritance patterns like autosomal recessive and dominant modes, essential for understanding genetic disorders.

Keywords:

Allele Dominant Heterozygous Homozygous Inheritance Mutation Recessive

More Related Videos

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

Understanding Cerebellar Pattern Formation

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

Related Experiment Videos

Last Updated: Jan 6, 2026

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

Published on: August 8, 2017

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

Understanding Cerebellar Pattern Formation

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

Area of Science:

Medical Genetics
Genomics
Molecular Diagnostics

Background:

Human genetics is a rapidly advancing field in medicine.
Genetic data informs diagnostic algorithms and therapeutic strategies.
Molecular genetic diagnostics utilize germline DNA information.

Purpose of the Study:

To summarize classical inheritance patterns of human diseases.
To review nomenclature for pedigree analysis.
To highlight the role of germline genetic variants in disease transmission.

Main Methods:

Review of classical genetic inheritance patterns.
Summary of autosomal recessive and dominant inheritance.
Explanation of pedigree analysis nomenclature and features.

Main Results:

Most heritable human diseases follow an autosomal recessive pattern.
Inherited tumor syndromes often exhibit autosomal dominant inheritance.
Germline genetic variants (genotypes) determine disease phenotypes.

Conclusions:

Understanding inheritance patterns is key to interpreting genetic data.
Germline DNA analysis is fundamental for diagnosing hereditary conditions.
Classical genetics principles remain vital in modern medical practice.