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Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
The effects of resistance exercise training followed by de-training on irisin and some metabolic parameters in type 2
Hassan Tavassoli1, Ali Heidarianpour1, Mehdi Hedayati2
1Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Bu-Ali Sina University, Hamedan, Iran.
Background:
We investigated the effects of high-fat diet (HFD) consumption combined with diabetes induction, resistance exercise training (RET) and a de-training period on circulating irisin levels and selective metabolic parameters.
Material And Methods:
Rats were assigned to four groups (n = 8): healthy non-diabetic rats (NDC), non-diabetic rats that performed RET (NDR), sedentary HFD-fed/STZ-treated rats (HFD/STZ) and HFD-fed/STZ-treated rats that performed RET (HFD/STZ + RE).
Results:
HFD consumption reduced irisin level and Quicki (p < .01). After the 12-week period, levels of TC, TG, HOMA1-IR, HOMA2-IR and irisin were also lower in the HFD/STZ + RE group compared to the HFD/STZ group. Body weight and HOMA1-IR showed a positive (r = 0.558 and r = 0.538) whereas TC and LDL-C had a negative correlation (r = -0.461 and r = -0.630) with irisin level (p < .05).
Conclusions:
Irisin level increased along with the progress of obesity and T2DM. It seems that RET can attenuate the increase of irisin in those conditions by improvement of glucose/lipid metabolic disorders.
