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Published on: August 7, 2017
High immunoglobulin E level is associated with increased readmission in children with bronchopneumonia
1Department of Pediatrics, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai, China.
Insights
Children with higher immunoglobulin E (IgE) levels face increased risk of bronchopneumonia readmission. Elevated IgE may predict rehospitalization in pediatric patients, aiding in early intervention strategies.
Area of Science:
- Pediatric Pulmonology
- Allergy and Immunology
- Clinical Epidemiology
Background:
- Elevated immunoglobulin E (IgE) levels are linked to lower respiratory tract infections.
- Bronchopneumonia is a significant cause of pediatric respiratory illness.
- Understanding readmission predictors is crucial for effective patient management.
Purpose of the Study:
- To evaluate the association between immunoglobulin E (IgE) levels and 12-month bronchopneumonia-related readmission rates in children.
- To identify IgE as a potential predictor for pediatric bronchopneumonia rehospitalization.
Main Methods:
- A cohort of 1099 children over 1 year old diagnosed with bronchopneumonia was studied.
- Unplanned readmissions within 12 months post-discharge were recorded.
- Multivariate regression analysis identified risk factors for rehospitalization.
Main Results:
- The rehospitalization rate was 11.4%.
- Children with rehospitalization had significantly higher IgE levels, asthma prevalence, and longer hospitalization durations.
- Elevated IgE levels (OR 1.781) and IgE >3x upper limit (OR 2.037) significantly increased rehospitalization risk, especially when combined with asthma (OR 2.548).
Conclusions:
- Higher immunoglobulin E (IgE) levels in children over 1 year with bronchopneumonia correlate with increased rehospitalization risk within 12 months.
- Immunoglobulin E (IgE) levels can serve as a valuable predictor for rehospitalization in pediatric bronchopneumonia cases.
- Early identification of high-risk patients through IgE assessment can inform targeted interventions.
Background:
Increased immunoglobulin E (IgE) is associated with lower respiratory tract infections. The study aimed to evaluate the association between IgE and the rate of bronchopneumonia-related readmission within 12 months in children.
Methods:
A total of 1099 children aged over 1 year with bronchopneumonia, from 1 January 2015 to 31 December 2016, were enrolled. Unplanned readmissions within 12 months after discharge were observed. Multivariate regression analysis was used to identify independent risk factors for rehospitalization.
Results:
The rate of rehospitalization was 11.4% (125/1099). Compared to the nonreadmission children, IgE levels, the proportion of children with asthma and hospitalization duration were significantly higher in the readmission children (p < 0.05). Compared to the children with normal IgE (≤ 165 IU/ml) levels, the risk of rehospitalization was significantly higher in children with abnormal IgE [odds ratio (OR) 1.781, 95% confidence interval (CI) 1.209-2.624, p = 0.004]. Children with IgE level more than three times the upper limit had even higher risks of readmission (OR 2.037, 95%CI 1.172-3.540, p = 0.012). Meanwhile, the risk of readmission in children with abnormal IgE combined with or without bronchial asthma was significantly higher (OR 2.548 and 1.918, 95% CI 1.490-4.358 and 1.218-3.020, p = 0.001 and 0.005, respectively).
Conclusions:
Children aged over 1 year with bronchopneumonia who had higher IgE levels are at increased risk for rehospitalization within the first 12 months of the index hospitalization and IgE level may be used as a predictor of rehospitalization in children with bronchopneumonia.
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