Combination Lorcaserin and Nicotine Patch for Smoking Cessation Without Weight Gain

Area of Science:

• Pharmacology and Addiction Medicine
• Clinical Trials and Therapeutics

Background:

• Post-smoking cessation weight gain is a significant barrier for many individuals attempting to quit.
• Pharmacological interventions are crucial for supporting smoking cessation and managing associated side effects.

Purpose of the Study:

• To evaluate the efficacy of a combination therapy involving lorcaserin and nicotine patches for smoking cessation.
• To assess the impact of this combination on preventing weight gain after smoking cessation.

Main Methods:

• A randomized controlled trial involving 61 adult daily smokers.
• Participants received either lorcaserin (10 mg twice daily) plus nicotine patch (21 mg) or placebo plus nicotine patch for 12 weeks, with a 2-week pre-quit randomization period.
• Outcomes measured included smoking abstinence, weight change, craving relief, and sensory enjoyment of smoking.

Main Results:

• A 31.1% biochemically confirmed continuous smoking abstinence rate was observed.
• No significant weight gain occurred in participants who quit smoking (mean weight change = -0.16 kg).
• Lorcaserin reduced the sensory enjoyment of smoking and craving relief, correlating with successful cessation.

Conclusions:

• The combination of lorcaserin and nicotine patch is well-tolerated and effective for smoking cessation.
• This regimen successfully prevents post-cessation weight gain, addressing a major obstacle for smokers.
• This medication combination represents a viable treatment option for smokers, particularly those concerned about weight gain.