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Updated: Jan 6, 2026
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Iron-Catalyzed β-Alkylation of Alcohols
Léo Bettoni1, Sylvain Gaillard1, Jean-Luc Renaud1
1Normandie Univ., LCMT, ENSICAEN, UNICAEN, CNRS , 6 boulevard du Maréchal Juin , 14000 Caen , France.
Abstract:
β-Branched alkylated alcohols have been prepared in good yields using a double-hydrogen autotransfer strategy in the presence of our diaminocyclopentadienone iron tricarbonyl complex Fe1. The alkylation of some 2-arylethanol derivatives was successfully addressed with benzylic alcohols and methanol as alkylating reagents under mild conditions. Deuterium labeling experiments suggested that both alcohols (2-arylethanol and either methanol or benzyl alcohol) served as hydrogen donors in this cascade process.
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