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Updated: Jan 6, 2026
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Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
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Geographic Atrophy and OCT Angiography: Descriptive Study and Correlation With Autofluorescence
Ophthalmic Surgery, Lasers & Imaging Retina
|October 8, 2019
Summary
Geographic atrophy (GA) and choriocapillaris (CC) nonperfusion areas correlate strongly. CC degeneration may precede retinal pigment epithelium (RPE) loss in GA, indicating earlier disease progression.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Age-Related Macular Degeneration
Background:
- Geographic atrophy (GA) involves progressive loss of retinal pigment epithelium (RPE), photoreceptors, and choriocapillaris (CC).
- CC flow is severely impaired in patients with atrophic age-related macular degeneration (AMD).
Purpose of the Study:
- To compare GA area measured by optical coherence tomography angiography (OCTA) with CC nonperfusion area and fundus autofluorescence (FAF).
Main Methods:
- Prospective, observational, cross-sectional study involving patients with GA.
- OCTA and FAF imaging were performed.
- Manual measurements of CC nonperfusion area (OCTA) and GA area (FAF) were conducted.
Main Results:
- A strong correlation (r = 0.97) was found between GA area measured by FAF and CC nonperfusion area by OCTA.
- The mean GA area on FAF was 2.184 mm² and on OCTA was 2.349 mm² (P = .035).
- CC nonperfusion area was larger than GA area on FAF.
Conclusions:
- CC nonperfusion area correlates linearly with GA area assessed by FAF.
- CC degeneration may precede RPE degeneration in GA.
- OCTA provides a reliable method for assessing GA progression.
