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Pathophysiology of Atopic Dermatitis and Psoriasis: Implications for Management in Children

Raj Chovatiya1, Jonathan I Silverberg2

  • 1Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. raj.chovatiya@gmail.com.

Children (Basel, Switzerland)
|October 9, 2019
PubMed

Insights

Atopic dermatitis (AD) and psoriasis are chronic inflammatory skin diseases. New insights into immune pathways are revolutionizing treatments, offering novel topical and systemic therapies for improved patient quality of life.

Area of Science:

  • Dermatology
  • Immunology
  • Pathophysiology

Background:

  • Atopic dermatitis (AD) and psoriasis are chronic inflammatory skin diseases with significant patient burden.
  • Both conditions involve immune dysregulation, skin barrier issues, genetics, and environmental factors.

Purpose of the Study:

  • To review the complex pathophysiology of AD and psoriasis.
  • To discuss current and emerging therapeutic strategies for these conditions.

Main Methods:

  • Literature review of pathophysiology and treatment options for AD and psoriasis.
  • Analysis of immune pathways, including T-helper cell involvement.

Main Results:

  • AD and psoriasis share common etiological factors but differ in specific immune pathways (Th2 in AD, Th1/Th17 in psoriasis).
  • Therapeutic approaches have evolved from broad anti-inflammatories to targeted therapies.

Conclusions:

  • Understanding specific immune dysregulation in AD and psoriasis has led to a therapeutic revolution.
  • Novel topical and systemic treatments are available and under investigation, offering improved management options.

Keywords:
atopic dermatitisbiologic therapycytokineinflammationpsoriasisskin-barriersystemic therapytopical therapy

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