The lateral prefrontal cortex and human long-term memory
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Updated: Jan 6, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Robert S Blumenfeld1, Charan Ranganath2
1Department of Psychology, California State Polytechnic University, Pomona, CA, United States.
Abstract:
Recent research has demonstrated that the lateral prefrontal cortex is extensively involved in human memory, including working memory processes that support retention of information across short delays, and episodic long-term memory encoding and retrieval processes. This chapter reviews results from neuroimaging studies of memory, from noninvasive brain stimulation studies of memory, and from studies of memory in patients with prefrontal lesions. The available evidence is consistent with the idea that different prefrontal regions implement cognitive or executive control processes that support working memory and episodic long-term memory encoding and retrieval.
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