Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

953
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
953
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.3K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.3K
Lateralization01:28

Lateralization

920
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
920
Working Memory01:24

Working Memory

751
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
751
Lobes of the Cerebrum01:22

Lobes of the Cerebrum

3.8K
The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
3.8K
Long-term Potentiation01:35

Long-term Potentiation

58.1K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
58.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural language processing captures memory content associated with shared neural patterns at encoding and retrieval.

Communications psychology·2026
Same author

Guess quality moderates how semantic relatedness influences the pretesting effect.

Journal of experimental psychology. Learning, memory, and cognition·2025
Same author

Anticipatory eye gaze as a marker of memory.

Communications psychology·2025
Same author

Saccades track visual associative memory processes with precision and sensitivity.

Brain communications·2025
Same author

Memory out of context: Spacing effects and decontextualization in a computational model of the medial temporal lobe.

Psychological review·2024
Same author

A complementary learning systems model of how sleep moderates retrieval practice effects.

Psychonomic bulletin & review·2024
Same journal

Preface.

Handbook of clinical neurology·2026
Same journal

Foreword.

Handbook of clinical neurology·2026
Same journal

Fundus autofluorescence imaging.

Handbook of clinical neurology·2026
Same journal

The electroretinogram as a means to study the physiology of the retina.

Handbook of clinical neurology·2026
Same journal

Adaptive optics scanning light ophthalmoscopy.

Handbook of clinical neurology·2026
Same journal

Modeling the human retina in a dish: Advances and future directions.

Handbook of clinical neurology·2026
See all related articles

Related Experiment Video

Updated: Jan 6, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.3K

The lateral prefrontal cortex and human long-term memory.

Robert S Blumenfeld1, Charan Ranganath2

  • 1Department of Psychology, California State Polytechnic University, Pomona, CA, United States.

Handbook of Clinical Neurology
|October 9, 2019
PubMed
Summary
This summary is machine-generated.

The lateral prefrontal cortex is crucial for human memory, supporting both short-term working memory and long-term episodic memory encoding and retrieval through executive control processes.

Keywords:
ControlEpisodicExecutiveFrontalFunctionalHumanLearningLesionLong termMagnetic resonance imagingMemoryMonkeyNeuroimagingNeuropsychologyPatientPrefrontalRecognitionSemanticShort termWorkingfMRI

More Related Videos

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

7.1K
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.8K

Related Experiment Videos

Last Updated: Jan 6, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.3K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

7.1K
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.8K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neuroimaging

Background:

  • The lateral prefrontal cortex plays a significant role in human memory functions.
  • Understanding its precise involvement in working memory and episodic memory is an active area of research.

Purpose of the Study:

  • To review and synthesize evidence on the lateral prefrontal cortex's role in memory.
  • To explore how different prefrontal regions contribute to cognitive control in memory processes.

Main Methods:

  • Review of neuroimaging studies (e.g., fMRI, PET).
  • Analysis of noninvasive brain stimulation studies (e.g., TMS, tDCS).
  • Examination of findings from patients with prefrontal cortex lesions.

Main Results:

  • The lateral prefrontal cortex is extensively involved in working memory, aiding short-delay information retention.
  • Evidence supports its role in both encoding and retrieval of episodic long-term memories.
  • Distinct prefrontal regions appear to implement specific executive control functions.

Conclusions:

  • The lateral prefrontal cortex is a key neural substrate for executive control in memory.
  • Cognitive control processes mediated by the prefrontal cortex are essential for working memory and episodic memory.
  • Future research should continue to elucidate the specific functions of prefrontal subregions in memory.