Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune phenotype heterogeneity in AML.

A Ost, B Christensson, R Andreasen

    Scandinavian Journal of Haematology
    |April 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Male reproductive health and intergenerational metabolic responses from a small RNA perspective.

    Journal of internal medicine·2020
    Same author

    A Randomized Comparison of Doxorubicin and Doxorubicin-DNA in the Treatment of Acute NonLymphoblastic Leukemia.

    Leukemia & lymphoma·2016
    Same author

    Expression of P-Glycoprotein in Non-Hodgkin's Lymphomas.

    Leukemia & lymphoma·2016
    Same author

    Fine-Needle Aspiration Cytology and Immunocytochemistry of Abdominal Non-Hodgkin's Lymphomas.

    Leukemia & lymphoma·2016
    Same author

    Nitric oxide and endothelin-1 release after one-lung ventilation during thoracoabdominal esophagectomy.

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2012
    Same author

    Entourage: the immune microenvironment following follicular lymphoma.

    Blood cancer journal·2012
    Same journal

    Role of iron in the proliferation of the established human tumor cell lines U-937 and K-562: effects of suramin and a lipophilic iron chelator (PIH).

    Scandinavian journal of haematology·1986
    Same journal

    The efficacy and toxicity of VAD in the treatment of myeloma and related disorders.

    Scandinavian journal of haematology·1986
    Same journal

    RES phagocytosis in children with homozygous beta-thalassemia in relation to blood transfusion.

    Scandinavian journal of haematology·1986
    Same journal

    Two allotypes of factor IX present in haemophilia B.

    Scandinavian journal of haematology·1986
    Same journal

    Radioimmunoassay of erythropoietin in chronic uraemia or anephric patients.

    Scandinavian journal of haematology·1986
    Same journal

    Prognostic significance of a morphometric study of lymph node biopsies in chronic lymphocytic leukaemia.

    Scandinavian journal of haematology·1986
    See all related articles

    This study analyzed surface markers on acute myeloid leukemia (AML) cells, finding significant antigenic heterogeneity. Certain marker expressions correlated with better complete remission rates, suggesting implications for AML classification and treatment.

    Area of Science:

    • Hematology
    • Immunology
    • Oncology

    Background:

    • Acute myeloid leukemia (AML) is a heterogeneous disease.
    • Understanding the immunophenotypic characteristics of AML is crucial for classification and treatment.
    • Surface marker expression on leukemic cells can provide insights into disease biology.

    Purpose of the Study:

    • To investigate the expression of various surface markers and Fc gamma receptors on blood cells from AML patients.
    • To compare the immunophenotypic profile of leukemic cells with normal bone marrow cells.
    • To explore the relationship between specific marker expression and complete remission rates in AML patients.

    Main Methods:

    • Studied blood cells from 46 AML patients and normal bone marrow cells.
    • Utilized a panel of 12 monoclonal antibodies for surface marker analysis.

    Related Experiment Videos

  • Assessed the expression of Fc gamma receptors on leukemic and normal cells.

    • Main Results:

    • Marked antigenic heterogeneity was observed in AML, even within FAB subclasses.
    • Leukemic cells in FAB subclass M1 expressed HLA class I antigen more frequently than in M5a.
    • Fc gamma receptor expression varied across FAB subclasses, being less frequent in M5a and more frequent in M1-M2, M4, and M5b.
    • High frequency of cells reacting with monoclonal antibody T50/12,11,2 correlated with better complete remission rates.

    Conclusions:

    • The immunophenotypic heterogeneity in AML reflects significant biological variability.
    • This variability has implications for the classification and treatment strategies of AML.
    • Specific surface marker expression may serve as a predictive marker for treatment response in AML.