Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lobes of the Cerebrum01:22

Lobes of the Cerebrum

3.8K
The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
3.8K
Association Areas of the Cortex01:21

Association Areas of the Cortex

8.7K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
8.7K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

953
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
953
Cerebrum: Anatomical Overview I01:26

Cerebrum: Anatomical Overview I

4.6K
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
4.6K
Three Developmental Domains01:29

Three Developmental Domains

902
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
902
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

6.2K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patterns of Change in Functional Connectivity and Motor Performance Are Different in Youth Recently Recovered from Concussion.

Neurotrauma reports·2025
Same author

Measuring Dyspraxia in Autism using a Five-Minute Praxis Exam.

Research in autism spectrum disorders·2023
Same author

OSARI, an Open-Source Anticipated Response Inhibition Task.

Behavior research methods·2021
Same author

Motor cortex modulation and reward in children with attention-deficit/hyperactivity disorder.

Brain communications·2021
Same author

Predicted DRD4 prefrontal gene expression moderates snack intake and stress perception in response to the environment in adolescents.

PloS one·2020
Same author

Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children.

Psychiatry research. Neuroimaging·2020

Related Experiment Video

Updated: Jan 6, 2026

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.4K

Development of the frontal lobe.

Keri Shiels Rosch1, Stewart Mostofsky1

  • 1Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, United States.

Handbook of Clinical Neurology
|October 9, 2019
PubMed
Summary

Frontal lobe development, crucial for decision-making and behavior, is shaped by feedback influencing fronto-subcortical circuits. Disruptions in these circuits are linked to developmental disorders like ADHD.

Keywords:
ADHDBehavioral approachBehavioral inhibitionCognitionExternalizingInternalizingMRIMotivationPunishmentReward

More Related Videos

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

7.8K
Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

13.3K

Related Experiment Videos

Last Updated: Jan 6, 2026

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.4K
Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

7.8K
Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

13.3K

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Behavioral Biology

Background:

  • Frontal lobe development is essential for complex cognitive functions and motivated behaviors.
  • Fronto-subcortical circuitry integrates feedback (reward, cost) to guide action selection based on goals.
  • Disruptions in this circuitry are implicated in developmental disorders and psychopathology.

Purpose of the Study:

  • To explore the role of frontal lobe development and fronto-subcortical circuitry in motivated behavior.
  • To understand how disruptions in these neural systems contribute to developmental disorders.
  • To frame neurobiological models of motivated behavior for a transdiagnostic perspective.

Main Methods:

  • The study reviews neurobiological models of motivated behavior.
  • It examines the functional specificity of frontal lobe regions and their subcortical connections.
  • It adopts a transdiagnostic, dimensional systems perspective.

Main Results:

  • Frontal lobe functions, including decision-making and action control, are modulated by contingency-based feedback.
  • Approach and avoidance behaviors are central to all behavior and rely on intact fronto-subcortical circuits.
  • Specific circuitry deficits determine the behavioral manifestations in developmental disorders.

Conclusions:

  • Neurobiologic models of motivated behavior offer a framework for understanding developmental disorders.
  • Characterizing approach-avoidance motivation across neurodevelopmental disorders is key.
  • This research can inform novel interventions and personalized medicine approaches.