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Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
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On Information Extraction and Decoding Mechanisms Improved by Noisy Amplification in Signaling Pathways
Aaron Vazquez-Jimenez1, Jesus Rodriguez-Gonzalez2
1Centro de Investigación y de Estudios Avanzados del IPN, Unidad Monterrey, Vía del conocimiento 201, Parque de Investigación e Innovación Tecnológica, 66600, Apodaca, NL, Mexico. VazqAaron@gmail.com.
Scientific Reports
|October 9, 2019
Summary
Cellular information decoding is enhanced by feed-forward loops and promoter affinity, acting as noisy amplifiers to improve signal transmission and channel capacity.
Area of Science:
- Cellular biology
- Systems biology
- Signal transduction
Background:
- Cells must process extracellular stimuli to generate appropriate responses.
- Information decoding within signaling pathways is crucial for cellular function.
- Eukaryotic cells utilize feed-forward loops and promoter affinity for information decoding.
Purpose of the Study:
- To investigate how feed-forward loops and promoter affinity enhance information transmission.
- To compare stochastic models of the MAPK/ERK pathway and minimal decoding models.
- To determine the maximal amount of transmittable information.
Main Methods:
- Stochastic modeling of the MAPK/ERK pathway.
- Stochastic minimal decoding model analysis.
- Computation of maximal transmittable information.
Main Results:
- The MAPK/ERK pathway's decoding mechanism improves channel capacity by acting as a noisy amplifier.
- Noisy amplification positively correlates with the amount of information extracted.
- Extrinsic noise can be tuned to enhance information transmission.
- Feed-forward loops and promoter affinity motifs extract information via amplification and noise addition.
Conclusions:
- Coupling feed-forward loops and promoter affinity enhances channel capacity.
- Decoding mechanisms exhibit novel characteristics in improving information transmission.
- Cellular information processing relies on amplification and controlled noise addition.
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