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Subcortical Volume Changes in Migraine with Aura.

Igor Petrusic1, Marko Dakovic2, Jasna Zidverc-Trajkovic3,4

  • 1Laboratory for Advanced Analysis of Neuroimages, Faculty of Physical Chemistry, University of Belgrade, Belgrade, Serbia. ip7med@yahoo.com.

Journal of Clinical Neurology (Seoul, Korea)
|October 9, 2019
PubMed
Summary

Migraine with aura (MwA) patients show smaller globus pallidus and left putamen volumes compared to healthy subjects. These subcortical structures may play a role in MwA pathophysiology.

Keywords:
basal gangliaglobus pallidusmigraine with auraputamen

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Area of Science:

  • Neuroscience
  • Radiology
  • Neurology

Background:

  • Migraine with aura (MwA) research has focused on cortical and white matter changes.
  • Subcortical structure morphology in MwA remains understudied.

Purpose of the Study:

  • To investigate subcortical brain structure differences between MwA patients and healthy subjects (HS).
  • To explore correlations between MwA characteristics and subcortical volumes.

Main Methods:

  • Thirty-two MwA patients and 32 age- and sex-matched HS were analyzed.
  • Subcortical brain volumes were automatically calculated using FSL software.
  • General linear models and partial correlation tests were employed.

Main Results:

  • MwA patients exhibited significantly smaller volumes in the right globus pallidus, left globus pallidus, and left putamen compared to HS.
  • No significant correlations were found between subcortical volumes and clinical migraine parameters.

Conclusions:

  • The globus pallidus and left putamen are implicated in the pathophysiology of MwA.
  • Further research is needed to establish causality due to the study's cross-sectional design.