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Pneumococcal polysaccharide immunization in infants and children.

M J Cowan, A J Ammann, D W Wara

    Pediatrics
    |November 1, 1978
    PubMed
    Summary

    Infants showed antibody responses to pneumococcal vaccine by 2 years, with significant responses to most types by 6-8 months. Type 3 responded early, while type 19 showed no significant response.

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    Area of Science:

    • Immunology
    • Pediatrics
    • Vaccinology

    Background:

    • Pneumococcal polysaccharide vaccines are crucial for preventing invasive pneumococcal disease.
    • Understanding infant antibody responses to pneumococcal vaccines is essential for optimizing immunization schedules.

    Purpose of the Study:

    • To evaluate antibody responses in infants and children to an octavalent pneumococcal polysaccharide vaccine.
    • To determine the age-related antibody response to specific pneumococcal serotypes.

    Main Methods:

    • Indirect hemagglutination assay used to measure antibody titers.
    • Study involved normal infants and children receiving an octavalent pneumococcal vaccine.

    Main Results:

    • Significant rise in antibody titers to most pneumococcal polysaccharide types by 2 years of age.

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  • By 6-8 months, 60% of infants responded to five of the eight vaccine types.
  • Type 3 elicited an early response (3 months), while type 19 showed no significant response.

    • Conclusions:

    • Recommended immunization at 6 months with a booster at 2 years, particularly for high-risk children.
    • Antibody response to pneumococcal polysaccharides is age-dependent, similar to other polysaccharide vaccines.