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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

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Should we reconsider the apoptosis as a strategic player in tissue regeneration?

Bruna Codispoti1, Irina Makeeva2, Jamal Sied3

  • 1Marrelli Health, Tecnologica Research Institute, Biomedical Section, Street E. Fermi, Crotone, Italy.

International Journal of Biological Sciences
|October 9, 2019
PubMed

Insights

Programmed cell death (apoptosis) is crucial for tissue regeneration. Understanding apoptosis regulators in stem cells offers new strategies for tissue engineering and treating diseases like cancer.

Area of Science:

  • Biomedical Science
  • Cell Biology
  • Regenerative Medicine

Background:

  • Apoptosis is vital for organ development and homeostasis.
  • Dysregulated apoptosis is linked to diseases including cancer and developmental disorders.
  • Recent research highlights apoptosis's connection to stem cells, tissue regeneration, and cancer.

Purpose of the Study:

  • To review recent discoveries on apoptosis's role in stem cells, particularly mesenchymal stem cells.
  • To identify key molecular players regulating apoptosis in stem cells.
  • To explore the potential of modulating apoptosis for tissue regeneration strategies.

Main Methods:

  • Literature review of recent scientific investigations.
  • Analysis of molecular mechanisms controlling apoptosis.
  • Examination of apoptosis's role in stem cell biology and tissue engineering.

Main Results:

  • Apoptosis is a promising area for regenerative medicine and tissue engineering.
  • Several molecular actors can switch apoptosis pathways on or off.
  • Modulating these actors may enable predictable tissue and organ regeneration.

Conclusions:

  • Apoptosis is a strategic factor in tissue regeneration.
  • Further understanding of apoptosis in stem cells can lead to novel regenerative therapies.
  • Mesenchymal stem cells are a key focus for exploring apoptosis-driven regeneration.
Keywords:
ApoptosisCell DeathMesenchymal Stem CellsRegenerative Medicine

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