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Related Experiment Videos

Fixed drug eruption.

B Gómez, J Sastre, J Azofra

    Allergologia Et Immunopathologia
    |March 1, 1985
    PubMed
    Summary

    Fixed drug eruptions were diagnosed using oral provocation tests in 21 patients. This method proved useful, with negative basophil degranulation tests, and cotrimoxazole being the most common culprit drug.

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    Area of Science:

    • Dermatology
    • Clinical Immunology

    Background:

    • Fixed drug eruptions (FDE) are a type of localized cutaneous drug reaction.
    • Accurate diagnosis of FDE is crucial for patient management and avoiding further adverse events.

    Purpose of the Study:

    • To evaluate the diagnostic utility of oral provocation testing in patients with suspected fixed drug eruptions.
    • To identify common causative agents and characterize the clinical presentation of FDE.

    Main Methods:

    • Conducted oral provocation tests with sub-therapeutic doses of suspected drugs in 21 patients with FDE.
    • Monitored for the appearance of characteristic lesions on skin or mucous membranes.
    • Performed basophil degranulation tests in a subset of patients.

    Main Results:

    • Oral provocation tests were positive in all 21 patients, confirming FDE diagnosis.
    • Lesions appeared within 20 minutes to 10 hours post-ingestion.
    • Basophil degranulation tests were consistently negative.
    • Cotrimoxazole was the most frequently implicated drug (71%), followed by neomycin in one case.

    Conclusions:

    • Oral provocation testing is a highly useful and reliable diagnostic method for fixed drug eruptions.
    • The basophil degranulation test appears to have limited utility in diagnosing FDE.
    • Cotrimoxazole is a significant cause of FDE.

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