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Thyroid dysfunction in Down syndrome.

S M Pueschel, J C Pezzullo

    American Journal of Diseases of Children (1960)
    |June 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Patients with Down syndrome show higher thyroid-stimulating hormone (TSH) levels and a higher prevalence of thyroid dysfunction. This dysfunction is linked to lower intellectual function in individuals with Down syndrome.

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    Area of Science:

    • Endocrinology
    • Genetics
    • Pediatrics

    Background:

    • Down syndrome is associated with various health complications, including endocrine disorders.
    • Thyroid dysfunction is a known concern in the Down syndrome population.

    Purpose of the Study:

    • To investigate thyroid function in patients with Down syndrome.
    • To compare thyroid function between Down syndrome patients and a control group.
    • To explore the relationship between thyroid function and intellectual function in Down syndrome.

    Main Methods:

    • Comparative analysis of thyroid-stimulating hormone (TSH) and thyroxine (T4) levels.
    • Inclusion of 151 patients with Down syndrome and 89 age-matched siblings without Down syndrome.
    • Assessment of intellectual function (IQ) in relation to thyroid status.

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    Main Results:

    • Significantly higher mean TSH levels were observed in the Down syndrome group compared to controls.
    • No significant difference in mean T4 levels between the groups.
    • A trend of increasing TSH and decreasing T4 with age was noted in the Down syndrome group.
    • Patients with both abnormal TSH and T4 levels exhibited significantly lower intellectual function.

    Conclusions:

    • There is an increased prevalence of thyroid dysfunction in individuals with Down syndrome.
    • Thyroid dysfunction, particularly combined TSH and T4 abnormalities, correlates with reduced intellectual function in Down syndrome.
    • Routine thyroid function monitoring is recommended for patients with Down syndrome.